Watch full movie WHAT About HER? with english subtitles in 1280p Average ratng: 6,3/10 2013votes
Her - WordReference English dictionary, questions, discussion and forums. This third-person pronoun represents the objective, possessive, and dative cases of she. Her is objective as in give her the medal of honor, possessive as in her dog. Watch breaking news videos, viral videos and original video clips on CNN.com. Breastcancer.org is a non-profit organization dedicated to providing information and community to those touched by this disease. Learn more about our commitment to.
Some genes and the proteins they make can influence how a breast cancer behaves and how it might respond to a specific treatment. Cancer cells from a tissue sample can be tested to see which genes are normal and abnormal. The proteins they make can also be tested. HER2 (human epidermal growth factor receptor 2) is one such gene that can play a role in the development of breast cancer. Your pathology report should include information about HER2 status, which tells you whether or not HER2 is playing a role in the cancer. The HER2 gene is also called the ERBB2 (Erb- B2 receptor tyrosine kinase 2) gene, so you may see it referred to by that name in some studies.
The results of the IHC test can be: 0 (negative), 1+ (also negative), 2+ (borderline), or 3+ (positive — HER2 protein overexpression). FISH test (Fluorescence In Situ Hybridization): The Fluorescence In Situ Hybridization test finds out if there are too many copies of the HER2 gene in the cancer cells. The results of the FISH test can be positive (HER2 gene amplification) or negative (no HER2 gene amplification). SPo. T- Light HER2 CISH test (Subtraction Probe Technology Chromogenic In Situ Hybridization): The SPo. T- Light test finds out if there are too many copies of the HER2 gene in the cancer cells.
The results of the SPo. T- Light test can be positive (HER2 gene amplification) or negative (no HER2 gene amplification).
Inform HER2 Dual ISH test (Inform Dual In Situ Hybridization): The Inform HER2 Dual ISH test finds out if there are too many copies of the HER2 gene in the cancer cells. The results of the Inform HER2 Dual ISH test can be positive (HER2 gene amplification) or negative (no HER2 gene amplification).
It's important to know which HER2 status test you had. Generally, only cancers that test IHC 3+, FISH positive, SPo. T- Light HER2 CISH positive, or Inform HER2 Dual ISH positive respond to the medicines that target HER2- positive breast cancers. Watch Captives online with subtitles in. An IHC 2+ test result is called borderline. If you have an IHC 2+ result, ask to have the tissue retested with a more precise HER2 test: the FISH test, SPo. T- Light HER2 CISH test, or the Inform HER2 Dual ISH test. Research has shown that some breast cancers that are HER2- positive can become HER2- negative over time.
Likewise, a HER2- negative breast cancer can become HER2- positive over time. If the breast cancer comes back in the future as advanced disease, doctors should consider ordering another biopsy and retest the tissue’s HER2 status. Treatments for HER2- positive breast cancer.
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There are some. treatments available specifically for HER2- positive breast cancer. They are: Herceptin (chemical name: trastuzumab).
HER2- positive breast cancers by blocking the ability of the cancer cells to receive chemical signals that tell the cells to grow. Kadcyla (chemical name: T- DM1 or ado- trastuzumab emtansine), a combination of Herceptin and the chemotherapy medicine emtansine.
Kadcyla was designed to deliver emtansine to cancer cells in a targeted way by attaching emtansine to Herceptin. Herceptin then carries emtansine to the HER2- positive cancer cells. This is probably because different labs have different rules for classifying positive and negative HER2 status. Each pathologist also may use slightly different criteria to decide whether the results are positive or negative.
In most cases, this happens when the test results are borderline — meaning they aren't strongly HER2- positive or HER2- negative. In other cases, tissue from one area of a breast cancer can test HER2- positive and tissue from a different area of the cancer can test HER2- negative. Inaccurate HER2 test results may cause women diagnosed with breast cancer to not get the best care possible. If all or part of a breast cancer is HER2- positive but test results classify it as HER2- negative, doctors aren't likely to recommend anti- HER2 treatment — even though the woman could potentially benefit from Herceptin, Kadcyla, Perjeta, or Tykerb. If a breast cancer is HER2- negative but test results classify it as HER2- positive, doctors may recommend anti- HER2 treatment — even though the woman is unlikely to get any benefits and is exposed to the medicines' risks. If your HER2 test results are HER2- negative, you may want to ask your doctor about how confident he or she is in the lab that did the HER2 testing and if another HER2 test might make sense for your unique situation.
If your HER2 test results are borderline, it's a good idea to ask if another HER2 test makes sense for you. Your Guide to the Breast Cancer Pathology Report is an on- the- go reference booklet you can fill out with your doctor or nurse to keep track of the results of your pathology report. Order a free booklet by mail or download the PDF of the booklet to print it at home.
